MyBioSource.com's MARCH8 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The MARCH8 Antibody was generated using MARCH8 as the antigen and it reacts with Human.
Description
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
Subunit Structure: Interacts with CD86.
Similarity: The RING-CH-type zinc finger domain is required for E3 ligase activity